According to our computer model, the Buffalo Bills will defeat the Miami Dolphins when the two teams match up at Highmark Stadium on Thursday, Sept. 18, which begins at 8:15 p.m. ET. For our predictions on the spead, point total, and final score, see the rest of the article below.
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Bills vs. Dolphins Game Info and TV Channel
- When: Thursday, September 18, 2025 at 8:15 p.m. ET
- Where: Highmark Stadium in Orchard Park, New York
- TV: Amazon Prime Video
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Prime Video (Regional restrictions may apply)
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Bills vs. Dolphins Odds and Betting Info
- Spread favorite: Bills (-11.5)
- Moneyline: Bills (-870), Dolphins (+588)
- Total: 50.5 points
Bills vs. Dolphins Prediction
- Pick ATS: Bills (-11.5)
- Pick OU: Under (50.5)
Prediction:
Bills 32 - Dolphins 15
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Bills vs. Dolphins Betting Insights
- The Bills have won two games against the spread this season.
- The Dolphins are winless against the spread this year (0-2-0).
- Bills games have gone over the point total once this season.
- Dolphins games have hit the over once this year.
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