When the Tampa Bay Buccaneers match up with the San Francisco 49ers at 4:25 p.m. ET on Sunday, Oct. 12, our computer model predicts the Buccaneers will take home the win. Our model also projects the spead, point total, and final score, which you can read below.
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Buccaneers vs. 49ers Game Info and TV Channel
- When: Sunday, October 12, 2025 at 4:25 p.m. ET
- Where: Raymond James Stadium in Tampa, Florida
- TV: CBS
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Buccaneers vs. 49ers Odds and Betting Info
- Spread favorite: Buccaneers (-3.5)
- Moneyline: Buccaneers (-186), 49ers (+153)
- Total: 46.5 points
Buccaneers vs. 49ers Prediction
- Pick ATS: 49ers (+3.5)
- Pick OU: Over (46.5)
Prediction:
Buccaneers 24 - 49ers 23
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Buccaneers vs. 49ers Betting Insights
- The Buccaneers have put together a 3-2-0 ATS record so far this year.
- The 49ers have put together a 3-2-0 record against the spread this year.
- Buccaneers games have gone over the point total three out of five times this season.
- In 2025, three 49ers games have hit the over.
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