Photo: MARTIN KEEP / AFP / Getty Images
The San Francisco 49ers are expected to win their matchup against the Miami Dolphins at 4:25 p.m. ET on Sunday, Sept. 20, based on our computer model. If you're seeking more projections on the final score, spread, and point total, we list those numbers below.
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Dolphins vs. 49ers Game Info and TV Channel
- When: Sunday, September 20, 2026 at 4:25 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
Dolphins vs. 49ers Odds and Betting Info
- Spread favorite: 49ers (-13.5)
- Moneyline: 49ers (-971), Dolphins (+640)
- Total: 45.5 points
Dolphins vs. 49ers Prediction
- Pick ATS: 49ers (-13.5)
- Pick OU: Under (45.5)
Prediction:
49ers 32 - Dolphins 5
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Dolphins vs. 49ers Betting Insights (2025 Stats)
- The 49ers went 11-6-0 ATS last season.
- The Dolphins went 8-9-0 ATS last year.
- San Francisco won its only game last season when playing as at least 13.5-point favorites.
- Miami covered the spread once when an underdog by 13.5 points or more last season (in two opportunities).
- Last season, the combined scoring went over the point total 10 times in 49ers games.
- The Dolphins and their opponent combined to hit the over 10 out of 17 times last year.
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